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It has become clear that vitamin D deficiency needs to be corrected at multiple levels: (i) vitamin D supplements and/or vitamin D-rich foods need to be consumed to provide adequate vitamin D, (ii) the body needs to be able to upregulate vitamin D-metabolizing genes to convert vitamin D into 25(OH)VD and then to 1,25(OH) 2 VD, and (iii) the levels of inflammatory biomarkers need to be reduced

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Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts[J] J